Title of article :
Synthesis and structure of a 1:1 co-crystal of hexa­methyl­ene­tetra­mine carb­­oxy­borane and acetamino­phen
Author/Authors :
Ayudhya, Theppawut Department of Chemistry - University of Texas Permian Basin, USA , Raymond, Casey Department of Chemistry - State University of New York at Oswego - Oswego, New York, USA , Dingra, Nin Department of Chemistry - University of Texas Permian Basin, USA
Pages :
12
From page :
1
To page :
12
Abstract :
Hexa­methyl­ene­tetra­mine carboacetamino­phenborane, a mol­ecule with two pharmacophores attached to a central carb­oxy­borate moiety, was synthesized and crystals were grown with an acetamino­phen co-crystal former to result in the title 1:1 co-crystal [hexa­methyl­ene­tetra­mine 4-acetamido­phenyl 2-boranyl­acetate–4-acet­amido­phenol (1/1)], C15H22BN5O3·C8H9NO2. In the first of these mol­ecules, both the borate-ester and acetyl­amino groups are considerably twisted away from the plane of the inter­vening benzene ring [dihedral angles = 76.89 (9) and 65.42 (9)°, respectively]. The extended structure of this co-crystal features N—H⋯O and O—H⋯O hydrogen bonds, which link the components into (100) sheets and weak C—H⋯O hydrogen bonds help to consolidate the structure.
Keywords :
co-crystal structure , CORCB , amine carb­oxy­borane , acetamino­phen
Journal title :
Acta Crystallographica Section E: Crystallographic Communications
Serial Year :
2020
Full Text URL :
Record number :
2622520
Link To Document :
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