Title of article :
Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
Author/Authors :
Dada, Deborah I. Department of Medical Laboratory Science - School of Public and Allied Health - Babcock University - Ilishan-Remo - Ogun State, Nigeria , Okoye, Jude O. Department of Medical Laboratory Science - School of Public and Allied Health - Babcock University - Ilishan-Remo - Ogun State, Nigeria , Ngokere, Anthony A. Department of Medical Laboratory Science - Faculty of Health Sciences and Technology - College of Medicine - Nnamdi Azikiwe University - Nnewi campus - Anambra, Nigeria , Onyenekwe, Charles C. Department of Medical Laboratory Science - Faculty of Health Sciences and Technology - College of Medicine - Nnamdi Azikiwe University - Nnewi campus - Anambra, Nigeria , Omotuyi, Olaposi Department of Biochemistry - Centre for Biotechnology - Adekunle Ajasin University - Akungba-Akoko - Ondo, Nigeria
Abstract :
This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.
Keywords :
epithelial-mesenchymal transition , microRNAs , Epstein-Barr virus , human papilloma virus , herpes simplex virus 2
Journal title :
African Journal of Laboratory Medicine
