Author/Authors :
Nedoszytko, Bogusław Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Lange, Magdalena Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Sokołowska-Wojdyło, Małgorzata Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Renke, Joanna Department of General and Medical Biochemistry - University of Gdansk, Poland , Trzonkowski, Piotr Department of Clinical Immunology and Transplantology - Medical University of Gdansk, Poland , Sobjanek, Michał Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Szczerkowska-Dobosz, Aneta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Niedoszytko, Marek Department of Allergology - Medical University of Gdansk, Poland , Górska, Aleksandra Department of Pulmonology - Medical University of Gdansk, Poland , Romantowski, Jan Department of Allergology - Medical University of Gdansk, Poland , Czarny, Justyna Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Skokowski, Jarosław Department of Oncological Surgery - Medical University of Gdansk, Poland , Kalinowski, Leszek Department of Medical Laboratory Diagnostic - Central Bank of Frozen Tissues and Genetic Specimens - Medical University of Gdansk, Poland , Nowicki, Roman Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland
Abstract :
Regulatory FOXP3+ T cells (Tregs) constitute 5% to 10% of T cells in the normal human skin. They play an important role in the induction and maintenance of immunological tolerance. The suppressive effects of these cells are exerted by various mechanisms including the direct cytotoxic effect, anti-inflammatory cytokines, metabolic disruption, and modulation of the dendritic cells function. The deficiency of Treg cells number or function are one of the basic elements of the pathogenesis of many skin diseases, such as psoriasis, atopic dermatitis, bacterial and viral infections. They also play a role in the pathogenesis of T cell lymphomas of the skin (cutaneous T cell lymphomas – CTCL), skin tumors and mastocytosis. Here, in the second part of the cycle, we describe dysfunctions of Tregs in selected skin diseases.
