Author/Authors :
Magalhães, Maria Angélica Baron Department of Surgery - Faculty of Medicine - Universidade Federal de Minas Gerais (UFMG), Belo-Horizonte-MG, Brazil , Petroianu, Andy Department of Surgery - Faculty of Medicine - Universidade Federal de Minas Gerais (UFMG), Belo-Horizonte-MG, Brazil , Barbosa, Alfredo José Afonso Department of Pathology - Faculty of Medicine - UFMG, Belo Horizonte-MG, Brazil , Figueiredo, Juliano Alves Department of Surgery - Faculty of Medicine - UFMG, Belo-Horizonte-MG, Brazil , Alberti, Luiz Ronaldo Department of Surgery - Faculty of Medicine - UFMG, Belo-Horizonte-MG, Brazil , Ribas Filho, Jurandir Marcondes Department of Surgery - Faculty of Medicine - Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil
Abstract :
Purpose:
To evaluate the hepatic changes associated with gastric ischemia.
Methods:
Thirty male rabbits were studied, distributed in 3 groups (n=10). Group 1: ligature and section of the gastric vasculature and removal of the liver after three hours; Group 2: ligature and section of the gastric vasculature and removal of the liver after 6 hours; Group 3: ligature and section of the gastric vasculature and removal of the liver after 12 hours. Blood samples were collected immediately before surgery and after the determined time of ischemia in each group to evaluate the hepatic function. After the death of the rabbits, the liver was removed for macro and microscopic study.
Results:
An increase in aminotransferases and bilirubin occurred in groups 2 and 3. Total protein and albumin diminished in all of the animals. All of the rabbits from groups 2 and 3 presented hepatocellular necrosis.
Conclusion:
The devascularization of the stomach for a period of above three hours is associated with hepatic morphological and functional disorders.
Keywords :
Stomach , Ischemia , Inflammation , Liver , Rabbits
