Author/Authors :
Gelbrich, Thomas University of Innsbruck - Institute of Pharmacy, Austria , Kahlenberg, Volker University of Innsbruck - Institute of Mineralogy and Petrography, Austria , Adamer, Verena Sandoz GmbH - Biochemiestrasse 10, Austria , Nerdinger, Sven Sandoz GmbH - Biochemiestrasse 10, Austria , Griesser, Ulrich J. University of Innsbruck - Institute of Pharmacy, Austria
Abstract :
The title compound, 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid ethanol monosolvate, C16H16N2O3S·C2H6O, (I), displays intermolecular O—H⋯O and O—H⋯N bonds in which the carboxyl group of the febuxostat molecule and the hydroxyl group of the ethanol molecule serve as hydrogen-bond donor sites. These interactions result in a helical hydrogen-bonded chain structure. The title structure is isostructural with a previously reported methanol analogue.
Keywords :
crystal structure , solvate , pharmaceuticals , hydrogen bonding , isostructural
