Author/Authors :
Inchingolo, Francesco Dept. of Interdisciplinary Medicine - University of Bari, Italy , Vermesan, Dinu Dept. of Orthopedics and Trauma - University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania , Inchingolo, Alessio D. Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy , Malcangi, Giuseppina Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy , Santacroce, Luigi Ionian Dept - University of Bari, Italy , Scacco, Salvatore Dept. of Basic Medical Sciences Neurosciences and Sensory Organs - University of Bari, Italy , Benagiano, Vincenzo Dept. of Basic Medical Sciences Neurosciences and Sensory Organs - University of Bari, Italy , Girolamo, Francesco Dept. of Basic Medical Sciences Neurosciences and Sensory Organs - University of Bari, Italy , Cagiano, Raffaele Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy , Caprio, Monica Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy , Longo, Lucia University “La Sapienza”, Policlinico Umberto I, Roma, Italy , Abbianante, Antonia Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy , Inchingolo, Angelo M. Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy , Dipalma, Gianna Dept. of Interdisciplinary Medicine - University of Bari, Italy , Tarullo, Angelo Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy , Tattoli, Maria Dept. of Biomedical Sciences and Human Oncology - University of Bari, Italy
Abstract :
Phenytoin is normally used in epilepsy treatment. One of the side effect affecting a signifi-cative part of the treated patients is the gingival overgrowth. It could surely be a correlation between this stimulatory effect and the assessment of phenytoin in wound healing. In fact, some studies of the literature have shown that topical phenytoin promotes healing of traumatic wounds, burns and ulcers by decubitus or stasis (diabetic or venous) and we emphasize, in vitiligo, a particular attention into re-pigmentation. The related mechanism of action seems to be multifactorial. In the present paper topical phenytoin has been used as wound-healing agent in 19 documented cases of bedsores,divided in treated and placebo group. The used concentration of phenytoin was 5 mg/L dissolved in a water solution of 9 g NaCl /L (0.9% P/V of NaCl). Patches soaked with phenytoin solution were applied over the bedsores along 3 hours every 12 hours. Results showed that phenytoin treated patients healed their wounds sig-nificantly before (p<0.001) with respect to controls.(www.actabiomedica.it)
