Author/Authors :
Eken, Hüseyin Department of General Surgery - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Cimen, Orhan Department of General Surgery - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Cimen, Ferda Keskin Department of Pathology - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Kurnaz, Eray Department of General Surgery - Mengücek Gazi Training and Research Hospital, Erzincan, Turkey , Yildirim, Murat Department of General Surgery - Zile State Hospital, Tokat, Turkey , Tasova, Volkan Department of General Surgery - Amasya University, Turkey , Kurt, Nezahat Department of Biochemistry - Faculty of Medicine - Ataturk University, Erzurum, Turkey , Pehlivanoglu, Kamil Department of General Surgery - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Onk, Didem Department of Anesthesiology and Reanimation - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Bilgin, Asli Ozbek Department of Pharmacology - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey
Abstract :
Purpose:
To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods.
Methods:
Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours.
Results:
Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group.
Conclusion:
The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.
Keywords :
Taxifolin , Celiac Artery , Ischemia , Reperfusion , Rats
