Author/Authors :
Zirilli, Giuseppina Department of Human Pathology of Adulthood and Childhood - University of Messina, Messina, Italy , Santucci, Simona Department of Human Pathology of Adulthood and Childhood - University of Messina, Messina, Italy , Cuzzupè, Chiara Department of Human Pathology of Adulthood and Childhood - University of Messina, Messina, Italy , Corica, Domenico Department of Human Pathology of Adulthood and Childhood - University of Messina, Messina, Italy , Pitrolo, Elda Department of Human Pathology of Adulthood and Childhood - University of Messina, Messina, Italy , Salzano, Giuseppina Department of Human Pathology of Adulthood and Childhood - University of Messina, Messina, Italy
Abstract :
Background: No reviews have specifically addressed, to now, whether autoimmune polyglandular syndromes (APSs) may have a peculiar epidemiology and phenotypical expression in pediatric age. Objectives:To review the most recent literature data about the specific epidemiological and clinical peculiarities of APSs in childhood and adolescence. Design: The main features of the different APSs in pediatric age were compared among them. Conclusions: 1) Among the different APSs, the one that is most typical of pediatric age is APS-1; 2) APS-1 is not characterized only by the classical triad (chronic moniliasis-hyposurrenalism-hypoparath-yroidism) and its clinical spectrum is enlarging over time; 3)APS-2 may have a different epidemiological and clinical expression according to two different nosological classifications. (www.actabiomedica.it)
Keywords :
associations of autoimmune disorders , epidemiology , immunodeficiency , phenotypical expression
