Title of article :
An update on direct immunofluorescence for diagnosing dermatitis herpetiformis
Author/Authors :
Dmochowski, Marian Autoimmune Blistering Dermatoses Section - Department of Dermatology - Poznan University of Medical Sciences, Poland , Gornowicz-Porowska, Justyna Autoimmune Blistering Dermatoses Section - Department of Dermatology - Poznan University of Medical Sciences, Poland , Bowszyc-Dmochowska, Monika Cutaneous Histopathology and Immunopathology Section - Department of Dermatology, Poznan University of Medical Sciences, Poland
Pages :
4
From page :
655
To page :
658
Abstract :
This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term “granular C3 dermatosis” was proposed to name such a rash. Recent data on DH suggest that perhaps the very concept of DH that we are universally accepting now is misleading and should be revised.
Keywords :
dermatitis herpetiformis , direct immunofluorescence , diagnosis
Journal title :
Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii
Serial Year :
2019
Full Text URL :
Record number :
2624207
Link To Document :
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