Title of article :
Structural investigation of methyl 3-(4-fluorobenzoyl)-7-methyl-2-phenylindolizine-1-carboxylate, an inhibitory drug towards Mycobacterium tuberculosis
Author/Authors :
Hasija, Avantika Department of Chemistry - Indian Institute of Science Education and Research Bhopal, India , Bhandary, Subhrajyoti Department of Chemistry - Indian Institute of Science Education and Research Bhopal, India , Venugopala, Katharigatta N. Department of Pharmaceutical Sciences - College of Clinical Pharmacy - King Faisal University, Kingdom of Saudi Arabia , Chandrashekharappa, Sandeep Institute for Stem Cell Biology and Regenerative Medicine, India , Chopra, Deepak Department of Chemistry - Indian Institute of Science Education and Research Bhopal, India
Abstract :
The title compound, C24H18FNO3, crystallizes in the monoclinic centrosymmetric space group P21/n and its molecular conformation is stabilized via C—H⋯O intramolecular interactions. The supramolecular network mainly comprises C—H⋯O, C—H⋯F and C—H⋯π interactions, which contribute towards the formation of the crystal structure. The different intermolecular interactions have been further analysed via Hirshfeld surface analysis and fingerprint plots.
Keywords :
fingerprint plot , crystal structure , anti-TB activity drug , ntermolecular interactions , Hirshfeld surface analysis
Journal title :
Acta Crystallographica Section E: Crystallographic Communications
