Title of article :
Crystal structure of (R)-5-[(R)-3-(4-chloro­phen­yl)-5-methyl-4,5-di­hydro­isoxazol-5-yl]-2-methyl­cyclo­hex-2-enone
Author/Authors :
Oubella, Ali Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco , Ait Itto, My Youssef Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco , Auhmania, Aziz Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco , Riahi, Abdelkhalek Institut de Chimie Moléculaire de Reims - Moulin de la Housse, France , Daran, Jean-Claude Laboratoire de Chimie de Coordination, France , Auhmani, Abdelwahed Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco
Pages :
9
From page :
1
To page :
9
Abstract :
The title compound, C17H18ClNO2, was prepared and isolated as a pure diastereoisomer, using column chromatography followed by a succession of fractional crystallizations. Its exact structure was fully identified via 1H NMR and confirmed by X-ray diffraction. It is built up from a central five-membered di­hydro­isoxazole ring to which a p-chloro­phenyl group and a cyclo­hex-2-enone ring are attached in the 3 and 5 positions. The cyclo­hex-2-one and isoxazoline rings each exhibit an envelope conformation. The crystal packing features C—H⋯O, C—H⋯N and C—H⋯π inter­actions, which generate a three-dimensional network.
Keywords :
isoxazole derivatives , absolute configuration , natural products , pharmaceutical activities , crystal structure
Journal title :
Acta Crystallographica Section E: Crystallographic Communications
Serial Year :
2020
Full Text URL :
Record number :
2624358
Link To Document :
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