Author/Authors :
Oubella, Ali Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco , Ait Itto, My Youssef Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco , Auhmania, Aziz Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco , Riahi, Abdelkhalek Institut de Chimie Moléculaire de Reims - Moulin de la Housse, France , Daran, Jean-Claude Laboratoire de Chimie de Coordination, France , Auhmani, Abdelwahed Laboratoire de Synthése Organique et de Physico-Chimie Moléculaire - Département de Chimie - Faculté des Sciences, Morocco
Abstract :
The title compound, C17H18ClNO2, was prepared and isolated as a pure diastereoisomer, using column chromatography followed by a succession of fractional crystallizations. Its exact structure was fully identified via 1H NMR and confirmed by X-ray diffraction. It is built up from a central five-membered dihydroisoxazole ring to which a p-chlorophenyl group and a cyclohex-2-enone ring are attached in the 3 and 5 positions. The cyclohex-2-one and isoxazoline rings each exhibit an envelope conformation. The crystal packing features C—H⋯O, C—H⋯N and C—H⋯π interactions, which generate a three-dimensional network.
Keywords :
isoxazole derivatives , absolute configuration , natural products , pharmaceutical activities , crystal structure