Author/Authors :
Samotij, Dominik Department of Dermatology - University of Rzeszow, Poland , Nedoszytko, Bogusław Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Bartosińska, Joanna Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Batycka-Baran, Aleksandra Department of Dermatology - Venereology and Allergology - Wroclaw Medical University, Poland , Czajkowski, Rafał Department of Dermatology and Venereology - Faculty of Medicine - Ludwik Rydygier Medical College in Bydgoszcz - Nicolaus Copernicus University in Torun, Poland , Dobrucki, Iwona T Beckman Institute for Advanced Science and Technology - Urbana, IL, USA , Dobrucki, Lawrence W Beckman Institute for Advanced Science and Technology - Urbana, IL, USA , Górecka-Sokołowska, Magdalena Department of Dermatology - Sexually Transmitted Disorders and Immunodermatology - Jurasz University Hospital No. 1, Bydgoszcz, Poland , Janaszak-Jasienicka, Anna Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Poland , Krasowska, Dorota Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Kalinowski, Leszek Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Poland , Macieja-Stawczyk, Marta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Nowicki, Roman J Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Owczarczyk-Saczonek, Agnieszka Department of Dermatology - Sexually Transmitted Diseases and Clinical Immunology - University of Warmia and Mazury, Olsztyn, Poland , Płoska, Agata Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Poland , Purzycka-Bohdan, Dorota Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Radulska, Adrianna Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Poland , Reszka, Edyta Department of Molecular Genetics and Epigenetics - Nofer Institute of Occupational Medicine, Lodz, Poland , Siekierzycka, Anna Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Poland , Słomiński, Andrzej Department of Dermatology - Birmingham, AL, USA , Słomiński, Radomir department of Medicine - Division of Rheumatology - University of Alabama - Birmingham, AL, USA , Sobalska-Kwapis, Marta Biobank Lab - Department of Molecular Biophysics - Faculty of Biology and Environmental Protection - University of Lodz, Poland , Strapagil, Dominik biobank Lab - Department of Molecular Biophysics - Faculty of Biology and Environmental Protection - University of Lodz, Poland , Szczerkowska-Dobosz, Aneta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Szczęch, Justyna Department of Dermatology - University of Rzeszow, Poland , Żmijewski, Michał Department of Histology - Medical University of Gdansk, Poland , Adam, Reichc Department of Dermatology - University of Rzeszow, Poland
Abstract :
Psoriasis is a common, chronic, inflammatory, immune-mediated skin disease affecting about 2% of the world’s population. According to current knowledge, psoriasis is a complex disease that involves various genes and environmental factors, such as stress, injuries, infections and certain medications. The chronic inflammation of psoriasis lesions develops upon epidermal infiltration, activation, and expansion of type 1 and type 17 Th cells. Despite the enormous progress in understanding the mechanisms that cause psoriasis, the target cells and antigens that drive pathogenic T cell responses in psoriatic lesions are still unproven and the autoimmune basis of psoriasis still remains hypothetical. However, since the identification of the Th17 cell subset, the IL-23/Th17 immune axis has been considered a key driver of psoriatic inflammation, which has led to the development of biologic agents that target crucial elements of this pathway. Here we present the current understanding of various aspects in psoriasis pathogenesis.
