Author/Authors :
Owczarczyk-Saczonek, Agnieszka Chair and Department of Dermatology - Sexually Transmitted Diseases and Clinical Immunology - Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland , Purzycka-Bohdan, Dorota Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Nedoszytko, Bogusław Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Reich, Adam Department of Dermatology - University of Rzeszow, Poland , Szczerkowska-Dobosz, Aneta Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Bartosiñska, Joanna Chair and Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Batycka-Baran, Aleksandra Chair and Department of Dermatology - Venereology and Allergology - Wroclaw Medical University, Poland , Czajkowski, Rafał Chair and Department of Dermatology - Sexually Transmitted Diseases and Immunodermatology - Collegium Medicum in Bydgoszcz - Nicolaus Copernicus University in Torun, Poland , Dobrucki, Iwona T Beckman Institute for Advanced Science and Technology, Urbana, USA , Dobrucki, Lawrence W Beckman Institute for Advanced Science and Technology, Urbana, USA , Górecka-Sokołowska, Magdalena Chair and Department of Dermatology - Venereology and Allergology - Wroclaw Medical University, Poland , Janaszak-Jasiecka, Anna Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Poland , Kalinowski, Leszek Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Poland , Krasowska, Dorota Chair and Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Radulska, Adrianna Department of Pharmaceutical Biochemistry - Medical University of Gdansk, Poland , Reszka, Edyta Department of Molecular Genetics and Epigenetics - Nofer Institute of Occupational Medicine, Lodz, Poland , Samotij, Dominik Department of Dermatology - University of Rzeszow, Poland , Słominski, Andrzej Department of Dermatology - University of Alabama at Birmingham - Birmingham, USA , Słominski, Radomir Department of Medicine and Microbiology - Division of Clinical Immunology and Rheumatology - University of Alabama at Birmingham, USA , Sobalska-Kwapis, Marta Biobank Laboratory - University of Lodz, Poland , Stawczyk-Macieja, Marta Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Strapagiel, Dominik Biobank Laboratory - University of Lodz, Poland , Szczêch, Justyna Department of Dermatology - University of Rzeszow, Poland , Żmijewski, Michał Department of Histology - Medical University of Gdansk, Poland , Nowicki, Roman J. Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland
Abstract :
Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory mediators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support.
