مرکز منطقه ای اطلاع رساني علوم و فناوري - Pathogenesis of psoriasis in the “omic” era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis

Author/Authors :

Szczerkowska-Dobosz, Aneta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Krasowska, Dorota Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Bartosińska, Joanna Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Stawczyk-Macieja, Marta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Walczak, Aleksandra Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Owczarczyk-Saczonek, Agnieszka Department of Dermatology - Sexually Transmitted Diseases and Clinical Immunology - University of Warmia and Mazury, Olsztyn, Poland , Reich, Adam Department of Dermatology - University of Rzeszow, Poland , Batycka-Baran, Aleksandra Department of Dermatology - Venereology and Allergology - Wroclaw Medical University, Poland , Czajkowski, Rafał Department of Dermatology - Sexually Transmitted Disorders and Immunodermatology - Jurasz University Hospital No. 1, Bydgoszcz, Poland , Dobrucki, Iwona T Beckman Institute for Advanced Science and Technology, Urbana, IL, USA , Dobrucki, Lawrence W Beckman Institute for Advanced Science and Technology, Urbana, IL, USA , Górecka-Sokołowska, Magdalena Biobanking and Biomolecular Resources Research Infrastructure (BBMRI.PL), Gdansk, Poland , Janaszak-Jasiecka, Anna Department of Bioengineering - University of Illinois at Urbana-Champaign, USA , Kalinowski, Leszek Beckman Institute for Advanced Science and Technology, Urbana, IL, USA , Nowicki, Roman J Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Płoska, Agata Department of Bioengineering - University of Illinois at Urbana-Champaign, USA , Purzycka-Bohdan, Dorota Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Radulska, Adrianna Department of Bioengineering - University of Illinois at Urbana-Champaign, USA , Reszka, Edyta Department of Molecular Genetics and Epigenetics - Nofer Institute of Occupational Medicine, Lodz, Poland , Samotij, Dominik Department of Dermatology - University of Rzeszow, Poland , Siekierzycka, Anna Department of Bioengineering - University of Illinois at Urbana-Champaign, USA , Slominski, Andrzej T Department of Dermatology - University of Alabama at Birmingham, USA , Slominski, Radomir M Department of Medicine and Microbiology - Division of Clinical Immunology and Rheumatology - University of Alabama at Birmingham, USA , Sobalska-Kwapis, Marta Biobank Lab, Department of Molecular Biophysics - Faculty of Biology and Environmental Protection - University of Lodz, Poland , Strapagiel, Dominik Biobanking and Biomolecular Resources Research Infrastructure (BBMRI.PL), Gdansk, Poland , Szczęch, Justyna Department of Dermatology - University of Rzeszow, Poland , żmijewski, Michał A. Department of Histology - Medical University of Gdansk, Poland , Nedoszytko, Bogusław Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland

Abstract :

Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis as well as a complex pathogenesis. Genetic and environmental factors trigger the development of the immune-mediated auto-inflammatory response in different sites: skin, bone marrow, entheses and synovial tissues. Studies of the last two decades have changed the view of PsA from a mild, non-progressive arthritis to an inflammatory systemic disease with serious health consequences, not only associated with joint dysfunction, but also with an increased risk of cardiovascular disease and socioeconomic consequences with significantly reduced quality of life. The joint damage starts early in the course of the disease, thus early recognition and treatment with modern biological treatments, which may modify the natural history and slow down progression of this debilitating disease, is essential for the patient long-term outcome.