Author/Authors :
Fatemi, Mohammad Javad iran university of medical sciences - Hazrat Fatemeh Hospital, تهران, ايران , Seyed Foroutan, Kamal iran university of medical sciences - Hazrat Fatemeh Hospital, تهران, ايران , Kazemi Ashtiani, Abass iran university of medical sciences - Hazrat Fatemeh Hospital, تهران, ايران , Jafari Mansoori, Maryam qom university of medical sciences and health services, قم, ايران , Vaghardoost, Reza qazvin university of medical sciences, قزوين, ايران , Pedram, Sepehr iran university of medical sciences - Hazrat Fatemeh Hospital - Department of Clinical Sciences, Veterinary Fatuity, تهران, ايران , Hosseinpolli, Aidin iran university of medical sciences - Hazrat Fatemeh Hospital, تهران, ايران , Rajabi, Fatemeh tehran university of medical sciences tums, تهران, ايران , Mousavi, Jaber tehran university of medical sciences tums, تهران, ايران
Abstract :
BACKGROUND: Considering the common origin of skin and peripheral nervous system, a tube of dermal layer of skin hypothetically can be an ideal conduit for nerve reconstruction. An experimental study performed to evaluate the nerve regeneration of efficacy into a dermal tube. METHODS: Sixty male Wistar rats were used. A 10 mm gap was produced in right sciatic nerves. In group A the autogenous nerve grafts were used to bridge the defects. In group B vein conduit were use to reconstruct the gaps. In group C dermal tube were used to bridge the defects. Morphologic studies were carried out after 3 month. RESULTS: The density of nerve fibers was significantly higher in autogenous nerve graft group. The efficacy of nerve growth into the dermal tube group was significantly poor in comparison to other groups. CONCLUSIONS: In the present study, dermis was used as the nerve conduit for the first time. This study indicates that the dermal tube is not a suitable conduit for nerve regeneration till further studies to resolve the problems before clinical application.
Keywords :
Nerve Injury , Nerve Gap , Nerve Conduit , Dermal Tube , Autogenous Nerve Graft
