Analysis of serum peptidome patterns of patients stung by honey bees

Recently, the number of the people who died from bitten by honeybees is gradually increasing. Hymenoptera venom of component is extremely complicated, and can impact function of multi‑organ in vivo, such as intravascular hemolysis, rhabdomyolysis, acute renal failure, liver loss, heart loss, nervous system loss, disseminated intravascular coagulation, etc., Especially, the renal damage is common. Stings of Hymenoptera may lead to anaphylaxis. Anaphylaxis to insect stings has occurred in 3% of adults and can be fatal even on the first reaction. The body systems of patients stung by honey bees exert differentially expression proteins, which can threat human lives. 2‑D gel electrophoresis (2‑DE) combined with protein identification by mass spectrometry (MS) is the most classic technology used for proteomics and is now recognized as an accurate method to determine and quantify human proteins, can reduce inter‑gel variability and simplifying gel analysis. It is also a rapid and sensitive method.