MICROWAVE ASSISTED RAPID an‎d EFFICIENT SYNTHESIS PHARMACOLOGICAL EVALUATION OF 1,5-BENZOTHIAZEPINE

1,5-Benzothiazepines 4a-j have been synthesized in 75-90% yield by a microwave promoted condensation of 2-aminothiophenol 3 and various chalcones 2 in the presence of catalytic amount of glacial acetic acid using methanol as a reaction mediator. The work-up is simple and involves treatment with ice-cold water. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. All the compounds of this series have been evaluated for their Antibacterial activity.