Title of article :
SYNTHESIS, CHARACTERIZATION and DETERMINATION OF PARTITION COEFFICIENT OF SOME TRIAZOLO THIADIAZINYL CHLOROCOUMARIN DERIVATIVES FOR THEIR ANTIMICROBIAL ACTIVITY
Author/Authors :
Jayashree, B. S. Manipal University - Manipal College of Pharmaceutical Sciences - Department of Pharmaceutical Chemistry, India , Sahu, A.R. Al-Ameen College of Pharmacy - Department of Pharmaceutical Chemistry, India , Murthy, M. Srinivasa Al-Ameen College of Pharmacy - Department of Pharmaceutical Chemistry, India , Venugopala, K.N. Al-Ameen College of Pharmacy - Department of Pharmaceutical Chemistry, India
Abstract :
A series of triazolo-thiadiazinyl chlorocoumarins 10a-k have been synthesized and these compounds have been characterized by IR, 1H-NMR and mass spectral analysis. The partition coefficient which is ahydrophobic parameter was also determined for the newly svnthesized compounds and the same compounds have been evaluated for their antimicrobial activitv.
Arabic abstract :
تم تحضير مجموعة من triazolo-thiadiazinyl chlorocoumarins (10a-k) و قد تم التعرف عليها باستخدام تحاليل أطياف الأشعة تحت الحمراء, الطنين النووي المغناطيسي و طيف الكتلة, كذلك تم تقدير معامل التوزيع الذي هو عامل طرد الماء للمركبات الجديدة و بالإضافة إلى أنه تمت دراسة الفاعلية المضادة للجراثيم للمركبات المحضرة
Keywords :
Chlorocoumarin , Triazole , Thiadiazine , Antimicrobial activity , Partition coefficient
Journal title :
Journal of Saudi Chemical Society
Journal title :
Journal of Saudi Chemical Society
