Author/Authors :
El-Helby, A. A. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Cairo-Egypt , Amin, M. A. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Cairo-Egypt , El-Sawah, M. M. Zigazig University - Faculty of Pharmacy - Organic Chemistry Department, Egypt , Bayomi, A. H. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Cairo-Egypt , El-Azab, Adel S. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Cairo-Egypt , Sherbiny, F. F. Al-Azhar University - Faculty of Pharmacy - Pharmaceutical Chemistry Department, Cairo-Egypt
Abstract :
2-Amino-4- (substituted phenyl)-7,7-dimethyl- (substituted phenyl)-4,6,7,8-tetrahydro 1-quinoline-3-carboxylic acid amide, 2-Amino-1- (substituted phenyl)-7,7-dimethyl (substituted phenyl)-4,6,7,8-tetrahydro–1H-quinoline-3-carbonitrile-5-one, 5,10-Di[ (substituted phenyl)-8,8-dimethyl-5,8,9,10-tetrahydro-3H, 7H-pyrimido (4, 5-b)]quinoline-4, 6-dione, 4- (substituted phenyl)-3,4,5,6,7, 8-hexahydro-1Hquinoline-2-thione, 5-(substituted phenyl)-1,2,4,5,6,7,8,9-octahydro benzo[f] [1,2,4]triazepine-4-one and5-(substituted phenyl)-1,2,4,5,6,7,8,9-octahydro-1H-benzo[f][1,2,4]triazepine-3-thione were synthesized.The microbiological testing of some of synthesized compounds showed that, some of the tested compounds having antibacterial and antifungal activity using cephalexine and nystaine as standard antibacterial and antifungal agents respectively.
Arabic abstract :
في هذا البحث أمكن تشييد سلسلة من مشتقات الكينولين و بريميدو الكينولين وتراى أزيبين -3- أون و تراى أزيين -3- ثيون.
و تم التأكيد البنائي لهذه المركبات الجديدة بواسطة التحاليل الدقيقة و الأشعة تحت الحمراء و الرنين المغناطيسي و كذلك مطياف الكتلة و بإجراء المسح البيولوجي على هذه المركبات, أظهرت النتائج فعالية بعض هذه المركبات كمضادات للبكتيريا و الفطريات مما يوضح أمكانية منها في المجال التطبيقي
