Title of article
Redox regulation of signal transduction in mammalian cells
Author/Authors
Herrlich، Peter نويسنده , , Bohmer، Frank D. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
-34
From page
35
To page
0
Abstract
This mini-review addresses the mechanism of ultraviolet-light-induced activation of receptor tyrosine kinases. The experimental approach into this mechanism revealed the existence of redox regulation of signal transduction in mammalian cells. It is postulated that, in addition to responsiveness to oxidative attacks from outside, redox regulation of specific redox-sensitive proteins likely represents an important physiological mechanism.
Keywords
receptor tyrosine kinases , UV response , protein tyrosine phosphatases , platelet-derived growth factor receptor , chemical cross-linking , tributyltin , in-gel phosphatase assay , photo-aging , substrate trapping , ligand-independent activation of RTKs
Journal title
Biochemical Pharmacology
Serial Year
2000
Journal title
Biochemical Pharmacology
Record number
26277
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