Title of article :
Redox regulation of signal transduction in mammalian cells
Author/Authors :
Herrlich، Peter نويسنده , , Bohmer، Frank D. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
This mini-review addresses the mechanism of ultraviolet-light-induced activation of receptor tyrosine kinases. The experimental approach into this mechanism revealed the existence of redox regulation of signal transduction in mammalian cells. It is postulated that, in addition to responsiveness to oxidative attacks from outside, redox regulation of specific redox-sensitive proteins likely represents an important physiological mechanism.
Keywords :
receptor tyrosine kinases , UV response , protein tyrosine phosphatases , platelet-derived growth factor receptor , chemical cross-linking , tributyltin , in-gel phosphatase assay , photo-aging , substrate trapping , ligand-independent activation of RTKs
Journal title :
Biochemical Pharmacology
Journal title :
Biochemical Pharmacology
