A simple and environmentally benign method for the synthesis of bis(4-hydroxycoumarin) methane derivatives using Nano-CeO2

Coumarins are oxygenated heterocycles that play a structural role in many natural products and have numerous biological activities and therapeutic applications, including anticoagulant activity, antiviral activity, use as an antibiotic, spasmolytic activity, antimicrobial activity, anticancer activity, and antioxidant activity. They also have antifungal, anti-insect, and anti-inflammatory properties and are employed to prevent disease and regulate growth. In addition, they are utilized as food additives and cosmetics. Due to the critical applications of coumarin derivatives, the synthesis of these compounds is of great importance. In this research study, the CeO2 nanocatalyst was exploited as an available catalyst that is also thermally stable in the synthesis of these compounds.