A septic B-spline collocation method for solving nonlinear singular boundary value problems arising in physiological models

In this paper, we present a numerical method based on septic B-spline function for nonlinear singular second-order two-point boundary value problems, which depend on different physiological processes as thermal explosions problem and the steady state oxygen diffusion in a spherical cell with Michaelis–Menten uptake kinetics and distribution of heat sources in the human head. Septic B-spline method has a truncation error of O(h^8) and converges to the exact solution with O(h^6). The numerical problems show that our method is very effective. The resulting sets of differential equations are modified at the singular point and are treated by using septic B-spline for finding the numerical solution. The maximum absolute errors and the absolute residual errors are acceptable.