Title of article :
Relationship between vitamin D consumption during pregnancy and neonatal congenital heart disease
Author/Authors :
Arjmandnia ، Mohammad Hosein Qom University of Medical Sciences , Vahedian ، Mostafa Qom University of Medical Sciences , Yosefi ، Maryam Qom University of Medical Sciences , Amouei ، Mehrnam Rafsanjan University of Medical Sciences , Rezvan ، Sajad Rafsanjan University of Medical Sciences , Assi ، Mohammad Hossein Qom University of Medical Sciences , Siamaki ، Millad Qom University of Medical Sciences , Barati ، Akram Qom University of Medical Sciences , Naderi ، Amir Hossein Qom University of Medical Sciences , Sharifi ، Alireza Qom University of Medical Sciences
Abstract :
Background and Aim: Interactions between genetic and environmental factors, including modifiable maternal nutrition and lifestyle, play a significant role in the pathogenesis of most congenital heart defects (CHD). This study was conducted to investigate the relationship between periconceptional maternal vitamin D status and the prevalence of CHD in offspring. Materials and Methods: This casecontrol study was conducted on 660 neonates referring to Masoumeh Hospital, Qom, Iran, from April 2016 onwards. The subjects were divided into two groups of CHD and healthy patients. The instrument applied to collect the necessary data was a researchmade checklist including demographic data and risk factors related to the study, which was filled by mothers. Independent ttest and Chisquare test were used to analyze quantitative and qualitative variables, respectively. A logistic regression test was also utilized, and the pvalue of less than 0.05was considered significant. Results: The mean age of mothers was obtained as 30 years in both groups. It was revealed that 94 (28.5%) and 159 (48.2%) of mothers in the case and control groups consumed Vitamin D in pregnancy. There was a significant difference between vitamin D intake and CHD in the two groups(p lt;0/001). The economic status of 53.3% of families with CHD patients was reported to be low. According to the results, 70.6% of mothers in the case group were highly educated. Conclusion: Based on the results, vitamin D consumption during pregnancy was associated with the reduction of neonatal CHD. Moreover, economic status was found as another risk factor affecting the development of neonatal CHD.
Keywords :
Vitamin D , Congenital Heart Disease , Pregnancy
Journal title :
Journal of Vessels and Circulation
Journal title :
Journal of Vessels and Circulation