Comparing the Apelin Level in Hypertensive Patients Who Received Hypertension Drugs

Background: Apelin, an adipokine secreted from adipose tissue, plays an important role in regulating blood pressure and hypertension.[Objectives]The current study aimed to compare the plasma Apelin level in hypertensive patients under treatment with amlodipine, losartan, and amlodipine + losartan.[Methods]In this casecontrol study, the serum level of Apelin was compared in four groups of (A) Healthy subjects (n = 31); (B) Hypertensive patients, received amlodipine (n = 31); Hypertensive patients, received losartan (n = 45); and patients (n = 33) that received amlodipine and losartan. Apelin level in serum samples was measured using Human Apelin ELISA Kit according to the manufacturers’ instructions. Data were analyzed using SPSS version 19 (Chicago: SPSS Inc.), at the significant level of α = 0.05.[Results]The mean blood level of Apelin in the control group and groups receiving amlodipine, losartan, and amlodipine + losartan was 366.16 ± 36.04, 247.19 ± 27.77, 282.93 ± 47.08, and 289.84 ± 32.20 g/dl, respectively. Losartan + amlodipine group had a higher level of Apelin compared with amlodipine alone (P lt; 0.05).[Conclusions]This study demonstrated that Apelin has a definite protective effect in preventing hypertension. Also, according to the results, the reninangiotensinaldosterone system inhibitors, such as losartan, caused a higher increase in the Apelin, resulting in better blood pressure control.