Title of article :
Resolved of Respiratory Failure Following the Use Pulse-Doses of Methylprednisolone in a Cytokine Storm Related to 2019 novel coronavirus
Author/Authors :
Khederlou, Hamid Tehran Heart Center - Tehran University of Medical Sciences, Tehran, Iran , Rostamian, Abdolrahman Rheumatology Department - Imam Khomeini Hospital - Tehran University of Medical Sciences, Tehran, Iran , Nezhadseifi, Elham Rheumatology Department - Imam Khomeini Hospital - Tehran University of Medical Sciences, Tehran, Iran , Ebrahimi-louyeh, Hourvash Rheumatology Department - Imam Khomeini Hospital - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Since mid-December of 2019, an outbreak of pneumonia has been spread from Wuhan City, Hubei province, China, as a viral
pneumonia. After virus identification and isolation, the pathogen for this pneumonia was originally called 2019 novel
coronavirus (2019-nCoV). 2019-nCoV has been associated with progressive cytokine storm leading to a hyper-inflammatory
state that this state associated with respiratory failure. We hereby reported a known case of Rheumatoid arthritis, Hypertension
and Coronary artery bypass graft that confirmed 2019-nCoV and he was associated with progressive cytokine storm leading to
respiratory failure. After corticosteroid administration, respiratory failure and extremely high levels of IL6 responded
dramatically to pulse-doses of Methylprednisolone. We concluded that pulse-doses of Corticosteroids can be effective in
controlling and relieving cytokine storms and related respiratory failure.
Farsi abstract :
فاقد چكيده فارسي
Keywords :
Cytokine storm , Interleukin-6 , 2019 Novel coronavirus , Respiratory failure , Systemic corticosteroid
Journal title :
Rheumatology Research