Author/Authors :
Allahyari, Saeideh Faculty of Pharmacy - Tabriz University of Medical Science, Tabriz, Iran , Valizadeh, Hadi Drug Applied Research Center and Faculty of Pharmacy - Tabriz University of Medical Science, Tabriz, Iran , Zakeri-Milani, Parvin Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy - Tabriz University of Medical Sciences, Tabriz, Iran
Abstract :
Bortezomib (BTZ) as a specific proteasome inhibitor is used to inhibit proliferation and migration
of tumor cell in variety of cancers. Targeted delivery of this drug not only would minimize its
unwanted side effects but also might improve its efficacy. This purpose could be gotten through
different pathways but using efficient carriers may be the best one without using any additional
ingredients/ materials. Some polymer based nanoparticles with specific functional groups have
the ability to interact with boronic acid moiety in BTZ. This reaction might play an important
role not only in cancer targeting therapy but also in loading and release properties of this drug.
Novel modification such as making multifunctional or pH-sensitive nanocarriers, may also
improve anticancer effect of BTZ. This review might have remarkable effect on researchers’
consideration about other possible interactions between BTZ and polymeric nanocarriers that
might have great effect on its remedy pathway. It has the ability to brought bright ideas to their
minds for novel amendments about other drugs and delivery systems.
Keywords :
Polymer , Nanoparticle , Bortezomib , Interaction