Comparison of the Effects of Combination of Turmeric, Ginger and Cinnamon Hydroalcoholic Extracts with Metformin on Body Weight, Glycemic Control, Inflammation, Oxidative Stress and Pancreatic Histopatalogical Changes in Diabetic Rat

Background: Type 2 diabetes is a progressive disease. This study Compared effects of combination of turmeric, ginger and cinnamon hydroalcoholic extracts with metformin on body weight, glycemic control, inflammation, oxidative stress and pancreatic histopatalogical changes in diabetic rat. Methods: Rats were randomly assigned to four groups of 13 animals. Diabetes was induced by a single injection of streptozotocin (STZ, 65 mg/kg) and nicotinamide (110 mg/kg, 15 min before STZ injection). Normal control (NC) and diabetic control (DC) rats received 1 mL of distilled water and two other diabetic groups received either 300 mg/kg (HETGCC) or 100 mg/kg metformin for 6 weeks. Results: HETGCC and metformin significantly decreased serum glucose, glycated hemoglobin (HbA1c), Homeostatic Model Assessment for Insulin Resistance (HOMA index), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and malondialdehyde (MDA) levels and significantly increased high-density lipoprotein cholesterol (HDL-C) concentrations compared to DC group. A significant increase in the number and diameter of the islets of Langerhans (IL) and body weight was seen in HETGCC group compared to DC rats and a significant increase in quantitative insulin sensitivity check index (QUICKI) was observed in metformin treated group. HETGCC and metformin did not have significant effects on hsCRP, insulin and triglyceride (TG) concentrations in diabetic rats. Conclusion: HETGCC was shown to reduce the risk of diabetes and improve complications associated with diabetes such as hyperglycemia, dyslipidemia, oxidative stress, inflammation, histopathological statue of islets of Langerhans and weight loss in T2D patients.