Author/Authors :
Dehghani, Mohsen School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Bordbar, Mohammad Reza School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Salimi, Rezvan School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Shahramian, Iraj Pediatric Gastroenterology and Hepatology Research Center - Zabol University of Medical Sciences, Zabol, Iran , Mirzae, Hadi Department of Biotechnology - Faculty of Medicine - Zabol University of Medical Sciences, Zabol, Iran , Gholami, Siavash School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Sharafi, Fatemeh Internal Medicine Department - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Bazi, Ali Department of Biotechnology - Faculty of Medicine - Zabol University of Medical Sciences, Zabol, Iran , Ataollahi, Maryam School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Fazeli, Fatemeh School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran , Hamzeloo, Samaneh School of Medicine - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Introduction: Almost all causes of chronic liver damage can culminate in liver fibrosis and
ultimately cirrhosis. Studies have suggested a relationship between mean platelet volume (MPV)
and liver fibrosis; however, this needs confirmation by further studies. We here assessed the
predictive value of MPV for liver fibrosis in children with chronic liver diseases.
Methods: In this study, children <18 years old with chronic liver diseases referred to the Nemazee
Hospital of Shiraz during 2013-2016 were studied. The patients underwent liver biopsy for
assessing liver fibrosis. Statistical analyses were conducted in SPSS 23.
Results: From 368 studied children, 52.2% were boys. The patients’ mean age was 4.5±3.9 years
old. Most patients had grade 6 fibrosis (36.7%). Cryptogenic (42.7%) was the most common
cause of chronic liver disease, and jaundice was the most prevalent clinical presentation (53%).
There was a significant association between the liver fibrosis and MPV (P = 0.025).
Conclusion: MPV was significantly different between patients with different severities of liver
fibrosis. However, assigning an appropriate cut off value to distinguish different degrees of
fibrosis requires more studies.
