Subgrouping of Iranian children and adolescents based on cardiometabolic risk factors using latent class analysis: The CASPIAN-V study

Background: Cardiometabolic syndrome indicates the clustering of several risk factors. The aims of this study were to identify the subgroups of the Iranian children and adolescents on the basis of the components of the cardio-metabolic syndrome and assess the role of demographic characteristics, socioeconomic status and lifestyle-related behaviors on the membership of participants in each latent class. Methods: This cross-sectional study was performed on 3730 Iranian students in 2015 using stratified cluster. All students in each class completed anonymous and structured questionnaires. Abdominal obesity, high triglyceride (TG), low high-density lipoprotein (HDL), high blood pressure (BP), high fasting blood sugar (FBS), high low-density lipoprotein (LDL), high cholesterol and obesity were used for assessing the pattern of cardio metabolic risk as a latent variable. Data analysis was performed using PROC LCA in SAS software. Results: Four latent classes were identified in this study; namely 1) healthy (59.6%), 2) low risk (20.4%), 3) moderate risk (13.7%) and 4) high risk (6.4%). Being a female (OR=0.59, 95% CI: 0.46-0.74), living in a rural area (OR=0.45, 95% CI;0.33-0.60), high screen time (OR=1.56, 95% CI:1.09-2.24), and parental obesity (OR=1.52, 95% CI: 1.18-1.95) were associated with moderate risk class. Only living in rural areas (OR=0.71, 95% CI; 0.51-0.99) was associated with high risk class. Conclusion: About 20% of the students are in the moderate risk and high risk classes. Design and implement interventions according to risk-based class that seem necessary by considering probably risk and protective factors for the prevention of complications of cardiometabolic syndrome.