Author/Authors :
Eslamijouybari, Mohammad Gastrointestinal Cancer Research Center - Non-Communicable Diseases Institute - Mazandaran University of Medical Sciences, Sari, Iran , Heydari, Keyvan Student Research Committee - School of Medicine - Mazandaran University of Medical Sciences, Sari, Iran , Maleki, Iradj Gut and Liver Research Center - Non- Communicable Diseases Institute - Mazandaran University of Medical Sciences, Sari, Iran , Moosazadeh, Mahmood Health Sciences Research Center - Addiction Institute - Mazandaran University of Medical Sciences, Sari, Iran , Hedayatizadeh-Omran, Akbar Gastrointestinal Cancer Research Center - Non-Communicable Diseases Institute - Mazandaran University of Medical Sciences, Sari, Iran , Vahedi, Lale Department of Pathology - Faculty of Medicine - Mazandaran University of Medical Sciences, Sari, Iran , Ghasemian, Roya Antimicrobial Resistance Research Center - Communicable Diseases Institute - Mazandaran University of Medical Sciences, Sari, Iran , Sharifpour, Ali Department of Pulmonary and Critical Care - Mazandaran University of Medical Sciences, Sari, Iran , Alizadeh-Navaei, Reza Gastrointestinal Cancer Research Center - Non-Communicable Diseases Institute - Mazandaran University of Medical Sciences, Sari, Iran
Abstract :
Background: The present study aimed to compare the complete blood count (CBC) indices
between COVID-19 patients and the control group, and assess the relationship of these
indices with COVID-19 prognosis.
Methods: COVID-19 patients (confirmed by PCR or CT-Scan) who visited Imam Hospital
in Sari were selected in this case-control study. The control group was selected from Tabari
cohort population matched with the case group in terms of gender and age. CBC, neutrophilto-
lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and outcome of the disease
(in the case group) were assessed in this study.
Results: The number of participants were 527 in both case and control groups, of which,
232 (44%) were females in each arms. Platelet count, lymphocyte count, and hemoglobin
concentration were also higher in the control group (P=0.000). NLR and PLR were
significantly higher in COVID-19 patients compared to the control group (P=0.000). NLR
had a significant relationship with the severity of the disease. NLR was two times higher in
the patients who died of COVID-19 than those who recovered (P=0.000). ROC curve
analysis for diagnostic values of NLR and PLR showed that the areas under the ROC curves
for NLR and PLR were 0.703 (95% CI: 0.64-0.76) and 0.535 (95% CI: 0.46-06), respectively.
Conclusion: NLR can be used as a prognostic marker for COVID-19 given the significant
difference of NLR between those who died and recovered from COVID-19.
Keywords :
Neutrophil-to-Lymphocyte ratio , Platelet-to-Lymphocyte ratio , COVID-19 , Prognosis
