Title of article :
Trends in the Incidence of Stomach Cancer in Golestan Province, a High-risk Area in Northern Iran, 2004–2016
Author/Authors :
Ghasemi-Kebria, Fatemeh Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Amiriani, Taghi Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Fazel, Abdolreza Cancer Research center - Golestan University of Medical Sciences - Gorgan - Iran , Naimi-Tabiei, Mohammad Cancer Research center - Golestan University of Medical Sciences - Gorgan - Iran , Norouzi, Alireza Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Khoshnia, Masoud Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , majidi, Mohammadreza Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Pooshani, Abdollah Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Mousaviemadi, Fatemeh Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Poorkhani, Houshang Department of Hematology/oncology - Golestan University of Medical Sciences - Gorgan - Iran , Sedaghat, Mehdi Deputy of Public Health - Golestan University of Medical Sciences - Gorgan - Iran , Salamat, Faezeh Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Hasanpour-Heidari, Susan Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Jafari-Delouie, Nastaran Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Gholami, Masoomeh Death registry unit - Deputy of Public Health - Golestan University of Medical Sciences - Gorgan - Iran , Semnani, Shahryar Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Roshandel, Gholamreza Golestan Research Center of Gastroenterology and Hepatology - Golestan University of Medical Sciences - Gorgan - Iran , Weiderpass, Elisabete International Agency for Research on Cancer - World Health Organization - Lyon - France , Malekzadeh, Reza Digestive Oncology Research Center - Digestive Diseases Research Institute - Tehran University of Medical Sciences - Tehran - Iran
Abstract :
Background: We aimed to present the temporal and geographical trends in the incidence of stomach cancer in the Golestan province, a high-risk area in Northern Iran.
Methods: This study was conducted on stomach cancer cases registered in the Golestan Population-based Cancer Registry (GPCR) during 2004-2016. Age-standardized incidence rates (ASRs) per 100000 person-years were calculated. The Joinpoint regression analysis was used to calculate the average annual percent changes (AAPC). We also calculated the contribution of population aging, population size and risk to the overall changes in incidence rates.
Results: Overall, 2964 stomach cancer patients were registered. The ASR of stomach cancer was significantly higher in men (26.9) than women (12.2) (P<0.01). There was a significant decreasing trend in incidence of stomach cancer in men (AAPC=-1.80, 95% CI: -3.30 to-0.28; P=0.02). We found a higher ASR of stomach cancer in the rural (21.4) than urban (18.1) (P=0.04) population, as well as a significant decreasing trend in its rates (AAPC=-2.14, 95% CI: -3.10to-1.17; P<0.01). The number of new cases of stomach cancer increased by 22.33% (from 215 in 2004 to 263 in 2016), of which 18.1%, 25.1% and -20.9% were due to population size, population aging and risk, respectively. Our findings suggest a higher rate for stomach cancer in eastern areas.
Conclusion: We found high incidence rates as well as temporal and geographical diversities in ASR of stomach cancer in Golestan, Iran. Our results showed an increase in the number of new cases, mainly due to population size and aging. Further studies are warranted to determine the risk factors of this cancer in this high-risk population.
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