Author/Authors :
KÖMÜRCÜ, Erkam Çanakkale 18 Mart University - Faculty of Medicine - Department of Orthopedics and Traumatology, Turkey , OKTAY, Murat Düzce University - Faculty of Medicine - Department of Pathology, Turkey , KAYMAZ, Burak Çanakkale 18 Mart University - Faculty of Medicine - Department of Orthopedics and Traumatology, Turkey , HATAY GÖLGE, Umut Çanakkale 18 Mart University - Faculty of Medicine - Department of Orthopedics and Traumatology, Turkey , GÖKSEL, Ferdi Çanakkale 18 Mart University - Faculty of Medicine - Department of Orthopedics and Traumatology, Turkey , NUSRAN, Gürdal Çanakkale 18 Mart University - Faculty of Medicine - Department of Orthopedics and Traumatology, Turkey
Abstract :
Objective: The aim of this study was to examine the role of coenzyme Q10 (CoQ10) in the preventionof steroid-induced osteonecrosis of the femoral head (ONFH) in rats. Methods: The study included 20 Sprague-Dawley rats injected once with 20 mg/kg of methylprednisolone acetate into the right gluteus medius muscle to induce osteonecrosis. Animals were divided into two equal groups; Group 1 received no prophylaxis (control group) and the Group 2 received CoQ10. Hematological examinations were performed before steroid injection (0 weeks) and at 4 weeks after steroid injection. Femoral heads were examined histologically to evaluate osteonecrosis. Results: Changes in blood glutathione (GSH) and malondialdehyde (MDA) concentrations were less significant in the CoQ10 group. The incidence of histologic changes consistent with early osteonecrosis was lower in the CoQ10 group (2 of 10; 20%) than the control group (7 of 10; 70%). Conclusion: Coenzyme Q10 may be useful as a preventing agent in steroid-induced ONFH. Inhibitedoxidative stress is a possible mechanism for this effect.
Keywords :
Coenzyme Q10 , glutathione , malondialdehyde , steroid , induced osteonecrosis
