Author/Authors :
Omoregie, Richard University of Benin Teaching Hospital - School of Medical Laboratory Science - Department Of Medical Microbiology, Department of Haematology and Blood Transfusion Science, Nigeria , Adeghe, Judith E. University of Benin Teaching Hospital - School Of Medical Laboratory Science - Department of Haematology and Blood Transfusion Science, Nigeria , Ogefere, Helen O. University of Benin Teaching Hospital - School of Medical Laboratory Science - Department Of Medical Microbiology, Nigeria , Omokaro, Evelyn U. University of Benin Teaching Hospital - School Of Medical Laboratory Science - Department of Haematology and Blood Transfusion Science, Nigeria , Ekeh, Chinedu C. University of Benin Teaching Hospital - School Of Medical Laboratory Science - Department of Haematology and Blood Transfusion Science, Nigeria
Abstract :
Objective: Human immunodeficiency virus (HIV)-infected patients, especially those on antiretrovirals are at risk of cardiovascular disease (CVD). The haemorheologic and fibrinolgtic activity of treatment naïve Nigerian HIV-infected patients were investigated. Methods: Blood was collected from 50 newly diagnosed treatment naïve HIV-infected patients and 50 apparently healthy HIV seronegative individuals that served as controls. Haematocrit values, plasma and serum viscosity, plasma fibrinogen concentration and euglobin lysis time were determined. Result: The mean ± standard deviation of haematocrit value of HIV infected patients (31.70 ± 6.33%) was significantly lower (p 0.0001) than those of controls (39.50 ± 2.43%). The plasma serum viscosity, plasma fibrinogen concentration and euglobin lysis time of HIV-infected patients were significantly higher compared with those of controls (p 0.0001). Conclusion: Treatment naive Nigerian HIV-infected patients have a defective blood flow and fibrinolytic system, which may predispose them to CVD.
Keywords :
Haemorheology , Fibrinolytic activity , HIV , Cardiovascular disease , HIV Treatment naïve , Nigerian.
