Title of article :
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Cote d Ivoire)
Author/Authors :
Yavo, W University of Cocody - Faculty of Pharmaceutical and Biological Sciences - Department of Parasitology and Mycology, Ivory Coast , Yavo, W National Institute of Public Health of Ivory Coast - Laboratory of Microbiology, Ivory Coast , Bla, KB University of Cocody - Faculty of Biosciences - Biochemical laboratory phamacodynamic, Ivory Coast , Djaman, AJ University of Cocody - Faculty of Biosciences - Biochemical laboratory phamacodynamic, Ivory Coast , Djaman, AJ University of Paris-Sud XI - Institute of integrative and cell biology of animals, France , Assi, SB Pierre Richet Institute of Bouake, Ivory Coast , Basco, LK Research Institute for Development - Malaria Research Unit 198, Cameroon , Mazabraud, A University Paris-Sud XI - Institute of integrative and cell biology of animals, France , Koné, M University of Cocody - Faculty of Pharmaceutical and Biological Sciences - Department of Parasitology and Mycology, Ivory Coast
Abstract :
Background: Malaria is the primary cause of hospitalization in Cote d Ivoire. Early treatment is one of the strategies to control this illness. However, the spread of resistance of Plasmodium falciparum to antimalarial drugs can seriously compromise this strategy. Objectives: The aim of this study was to assess the in vitro susceptibility of P. falciparum to monodesethylamodiaquine and aminoalcohols in Abidjan (Cote d Ivoire). Methods: We assessed the in vitro susceptibility of isolates collected from patients with uncomplicated malaria by using the WHO optical microtest technique. Results: The proportions of resistance to monodesethylamodiaquine, mÈfloquine and halofantrine were 12.5%, 15.6% and 25.9%, respectively. For quinine, none of isolates showed evidence of in vitro resistance. However, two isolates (6.1%) had IC50 values above 300 nM. The IC50 of each drug was positively and significantly correlated to that of the other three drugs, and the correlation was higher between halofantrine and mefloquine. Conclusions: Our results showed that the in vitro chloroquine resistance reported in previous studies has been extended to other antimalarial drugs investigated in this study except for quinine. Therefore, it is necessary to implement a long-term monitoring system of antimalarial drug resistance.
Keywords :
in vitro test , Plasmodium falciparum , monodesethylamodiaquine , quinine , mefloquine , halofantrine , Abidjan (Cote d Ivoire).
