Author/Authors :
Ebule, IA University of Yaounde - Faculty of Medicine and Biomedical Sciences - Department of Immunology, Faculty of Medicine and Biomedical Sciences, Cameroon , Ebule, IA Yaounde Initiative Foundation, Messa , Longdoh, AN University of Buea - Faculty of Health Sciences - Department of Medical Laboratory Sciences, Cameroon , Paloheimo, IL Biohit P.L.C., Finland , ebule, a.i. university of yaounde 1, Cameroon , longdoh, a.n. department of medical laboratory sciences, Cameroon , paloheimo, i.l. biohit p.l.c, Finland
Abstract :
Background: Helicobacter pylori-infection associated gastritis is known to be a significant risk factor of gastric cancer. Serum levels of Gastrin-17 and Pepsinogen1which are respectively biomarkers of gastric antral and corpus mucosal activity are well known parameters of atrophic gastritis. Objectives: To determine the prevalence of Helicobacter pylori and atrophic gastritis amongst dyspeptic patients and to compare the production of PGI and G-17 in the various atrophic stages. Methods: A total of 139 dyspeptic patients aged 46.68±15.50 years [females 106 aged47.23±15.51years, males 33 aged 44.48±14.62] were included during the one year period, March 2008-april 2009 at the district hospital Tombel. The degree of atrophy was determined by the levels of serum pepsinogen1, and gastrin-17 and the presence of Helicobacter pylori antibodies detected by an enzyme immunoassay. Results: The prevalence of Helicobacter pylori was 79.82% and that for atrophic gastritis was 6.6%. A decrease in mean serum levels of gastin-17 along with increasing antral atrophy was observed; the mean serum levels of pepsinogen1 were reduced during progression of corpus atrophy. Conclusion: A weak reverse correlation(r =-0.036) was found between Gastrin-17 and Helicobacter pylori antibodies
Keywords :
Helicobacter pylori , atrophic gastritis , gastrin , pepsinogen
