Author/Authors :
Chen, Xiong Central South University - Third Xiangya Hospital - Department of Gastroenterology, China , Wan, Ying-Chun Central South University - Third Xiangya Hospital - Department of Gastroenterology, China , Guo, Tao Central South University - Second Xiangya Hospital - Department of Gastroenterology, China , Xu, Can-Xia Central South University - Third Xiangya Hospital - Department of Gastroenterology, China , Wang, Fen Central South University - Third Xiangya Hospital - Department of Gastroenterology, China , chen, x. department of gastroenterology,the third xiangya hospital,central south university, China , wan, y.-c. department of gastroenterology,the third xiangya hospital,central south university, China , guo, t. department of gastroenterology,the second xiangya hospital,central south university, China , xu, c.-x. department of gastroenterology,the third xiangya hospital,central south university, China , wang, f. department of gastroenterology,the third xiangya hospital,central south university, China
Abstract :
Background:The infection of Helicobacter pylori (H. pylori) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H2S) production in H. pylori-induced gastric ulcer disease. Aim:The expression of cystathionine-γ-lyase (CSE) was determined, and correlated with the severity of gastric ulcer disease. Methods: One hundred and eight patients were selected based on the determination of gastric ulcer and the infection of Helicobacter pylori (H. pylori), including 36 normal control, 36 patients with H. Pylori-negative gastric ulcer, and 36 patients with H. Pylori-positive gastric ulcer. RT-PCR determination was performed to determine the expression of CSE, NF-κB and IL-8. Results:The expression of CSE, NF-κB and IL-8 was higher in the gastric ulcer group than control group (p 0.05). Compared with the H.pylori-negative gastric ulcer, the expression of CSE, NF-κB and IL-8 was higher than H.pylori-positive gastric ulcer group (p 0.05). For H.pylori-negative gastric ulcer group, the expression of CSE positively correlated with the expression of NF-κB (r=0.98, p 0.05) and IL-8 (r=0.95, p 0.05). For H.pylori-positive gastric ulcer group, the expression of CSE also positively correlated with the expression of NF-κB (r=0.99, p 0.05) and IL-8 (r=0.85, p 0.05). Conclusion: The expression of CSE was positively correlated with the severity of gastric ulcer.
Keywords :
Helicobacter pylori , gastric ulcer , hydrogen sulfide (H2S) , cystathionine , γ , lyase (CSE)
