Author/Authors :
Yan, Zhang Chinese PLA General Hospital - Department of Gynecology and Obstetrics, China , Chunxia, Qiao Institute of Basic Medical Sciences - Laboratory of Immunology, China , Lian, Li Inner Mongolia Medical University - College of Medical Sciences - Department of Microbiology, China , Xuye, Zhao Shanxi Tumor Hospital - Department of Gynecology and Obstetrics, China , Yali, Li Chinese PLA General Hospital - Department of Gynecology and Obstetrics, China , yan, z. department of gynecology and obstetrics, China , chunxia, q. laboratory of immunology, China , lian, l. department of microbiology,college of medical sciences, China , xuye, z. department of gynecology and obstetrics, China , yali, l. department of gynecology and obstetrics, China
Abstract :
Objective: This study measured the human epididymis protein 4 (HE4) and CA125 levels in Chinese women with benign gynecological disorders. Material and methods: Sera were obtained from Chinese women prior to surgery for a pelvic mass and HE4 and CA125 levels were determined. The proportions of patients with HE4 and CA125 levels were compared. Results: There were 68 Chinese women with benign diseases. HE4 levels were less elevated than CA125 (1% V.S. 29%, P 0.001). The significant difference was observed in patients with endometriosis/endometriomas in which HE4 was not elevated patients and CA125 was elevated in 53% (P 0.001). Serum HE4 level was not elevated in patients with cystadenoma (0% V.S. 23%, P 0.001) and in patients with germ cell tumors (0% V.S. 5%, P 0.001). Conclusion: HE4 was less elevated and more suitable as a biomarker than CA125 in chinese women with benign disease.
Keywords :
benign gynecological disease , biomarker , CA125 , HE4
