Author/Authors :
Mazandarani, Mahnaz tehran university of medical sciences tums - Faculty of Pharmacy - Department of Pharmacotherapy, تهران, ايران , Yousefshahi, Fardin tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesia and critical care, تهران, ايران , Abdollahi, Mohammad tehran university of medical sciences tums - Pharmaceutical Sciences Research Center, تهران, ايران , Hamishehkar, Hadi tabriz university of medical sciences - Faculty of Pharmacy - Department of Pharmacotherapy, ايران , Barkhordari, Khosro tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesia and critical care, تهران, ايران , Boroomand, Mohammad Ali tehran university of medical sciences tums - Faculty of Medicine - Department of Pathology, تهران, ايران , Jalali, Arash tehran university of medical sciences tums - Faculty of Statistics - Department of Epidemiology and Biostatistics, تهران, ايران , Ahmadi, Arezoo tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesia and critical care, تهران, ايران , Shariat Moharari, Reza tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesia and critical care, تهران, ايران , Bashirzadeh, Mona islamic azad university - School of Pharmacy - Department of Pharmacotherapy, ايران , Mojtahedzadeh, Mojtaba tehran university of medical sciences tums - Faculty of Pharmacy - Department of Pharmacotherapy, تهران, ايران
Abstract :
Background and the purpose of the study: Blood contact with artificial surfaces of the extracorporeal circuit and ischemia-reperfusion injury in CABG with CPB, may lead to a systemic inflammatory response. Hypertonic saline have been recently investigated as a fluid in order to decrease inflammatory response and cytokines generation in patients undergo cardiac operations. Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory IL-10 as an anti-inflammatory biomarker in CABG patients. Methods: The present study is a randomized double-blinded clinical trial. 40 patients undergoing CABG were randomized to receive HS 5% or NS before operation. Blood samples were obtained after receiving HS or NS, just before operation, 24 and 48 hours post-operatively. Plasma levels of IL-6 and IL-10 were measured by ELISA. Results and major conclusion: Patients received HS had lower levels of IL-6 and higher level of IL-10 compared with NS group, however these differences were not statistically significant. Results of this study suggest that pre-treatment with small volume hypertonic saline 5% may have beneficial effects on inflammatory response following CABG operation.
Keywords :
CABG , CPB , Hypertonic saline 5% , Inflammation , IL , 6 , IL , 10
