Intravitreal administration of bevacizumab: pros and cons

Bevacizumab (Avastin®, Genethech, Inc.) is a humanized monoclonal antibody that inhibits vascular endothelial growth factor (VEGF). It was first approved by the US food and drug administration for metastatic colorectal cancer and subsequently for cervical/ovarian/fallopian tube cancers, glioblastoma, non-small cell lung cancer, and metastaic renal cell carcinoma [1]. Recently its offlabel use for age-related macular degeneration (AMD) has received extensive attention.