Comparison of laparoscopic drilling by diathermy and laser for ovulation induction in clomiphene citrate-resistant women with polycystic ovary syndrome

Objective: The aim of the present study was to compare the effectiveness of laparoscopic ovarian drilling (LOD) with monopolar diathermy and CO2 laser on the serum levels of hormone and pregnancy outcome in clomiphene citrate(CC) resistant infertile women with polycystic ovarian syndrome (PCOS).Materials and Methods: Thirty women underwent laparoscopic ovarian diathermy (group A) and thirty women underwent laparoscopic ovarian laser (group B). Serum levels of LH, FSH, Testosterone and Progesterone,menstrual cycles regularity, ovulation and Pregnancy rates were compared between the two groups.Results: In this study, there was no significant difference in the main demographic, clinical and endocrinological characteristics between two groups. The percentage of women with PCOS resumed regular menstrual cycle in groupA and B was 73% and 76% respectively (P-value=0.5). There was no significant difference in hormonal profiles(LH, FSH, Testosterone and Progesterone) between two groups. Similarly, there was no statistically difference inthe total ovulation rate between two groups (40% vs.43.3% in group A and B respectively). Finally, there was no significant difference in the pregnancy and miscarriage rate in women with CC resistant PCOS undergoing diathermy compared with laser therapy.Conclusions: Both laparoscopic ovarian diathermy and laparoscopic ovarian laser have good effects on ovulation induction in PCOS women but none of these two methods had any obvious advantages over another method