Pregnancy outcome after multifetal reduction via early transvaginal embryo aspiration: Mansoura fertility care unit experience

Objective: To evaluate the pregnancy outcome after multifetal pregnancy reduction (MFPR) via early transvaginalembryo aspiration.Design: Prospective clinical studyMaterial and Methods: The study included 30 patients with high-order multifetal gestations (more than 3 fetuses),Pregnancies included, before reduction: 22 quadruplet gestations (group 1) and 6 quintuplets (group 2), and 2sextuplets (group 3). All pregnancies were reduced to twins. The primary outcome measures included procedurecomplications while the secondary ones were pregnancy outcomes.Results: The procedure was successfully completed in all cases. Miscarriage occurred in 2/30 patients (6.6%). Pretermdelivery occurred in 20/30 cases (66.6%). The incidence of early pregnancy complications and neonatal outcomes inreduced pregnancies were similar to that of the control group. However, the cesarean section rate of reduced twinpregnancies was significantly higher (P 0.05).Conclusion: Early transvaginal embryo aspiration is a safe, effective and simple operation. It is associated with reducedperinatal morbidity and mortality as well as minimal maternal complication.