Author/Authors :
Youssef, Hamed Mansoura University - Departments of Obstetrics and Gynecology, Egypt , El Deeb, Walaa Alexandria University - Departments of Obstetrics and Gynecology, Egypt , Shawky, Osama Cairo University - Departments of Obstetrics and Gynecology, Egypt , Metawe, Mohamed Suez Canal University - Departments of Obstetrics and Gynecology, Egypt , Goda, Hossam Suez CanalUniversity - Departments of Obstetrics and Gynecology, Egypt
Abstract :
Objective: to compare results of GnRH agonist long protocol vs. short protocol in women forty years or older undergoing ICS cyclesSetting: multicenter comparative trial Materials and methods: Participants Interventions: a total of 531 women ranging between 40-47ys were included in this study. Two hundred eighty five women received long protocol while two hundred forty six women received short protocol. All women had FSH less than 20 before start of treatment. Standard ICSI program was done and follow up for all cases. Women with previous poor response were excluded from the study.Results: In total, among 531 participants, clinical pregnancy was achieved in one hundred and one women (19%) and miscarriage rate was (32%) mainly in the first eight weeks. There was a wide variation in regarding both protocols (longprotocol achieved pregnancy rate of 26.6 % while short protocol achieved only 10.2% pregnancy rate (P 0.001). Nocases of severe OHSS were reported. Cost of drugs were significantly reduced with the short protocol (P =0.031)Conclusion: this multicenter study shows that long protocol of GnRH agonist was better than short protocol in women with age of forty or above.
