Author/Authors :
Movafagh, Abolfazl shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Hashemi, Mehrdad islamic azad university - Department of Genetics, ايران , Ghadiani, Mojtaba shahid beheshti university of medical sciences - Taleghani Hospital - Department of Internal Medicine/Oncology, تهران, ايران , Mirfakhraei, Reza shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Darvish, Hossein shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Zare Abdollahi, Davood shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Ghaedi, Hamid shahid beheshti university of medical sciences - Faculty of Medicine - Medical Genetics Department, تهران, ايران , Safari, Shamsi shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , HaghNejad, Leyla shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Mosammami, Sara shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Safavi Naeini, Niloofar shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Miri, Ramin shahid beheshti university of medical sciences - School of Medicine - Department of Medical Genetics, تهران, ايران , Rezaei Tavirani, Mostafa shahid beheshti university of medical sciences - Proteomics Research Center, تهران, ايران
Abstract :
Background: According to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. This study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations. Methods: We conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/chromosomes/Mitelman) databases in addition to other pertinent web references. In addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone marrow/peripheral blood cells obtained from the current case. Cells were finally treated by the giemsa-trypsin-giemsa banding technique. Results: The result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes 2, 5, 9, and 22. We performed karyotyping after the initiation of chemotherapy. Karyotyping results showed a complexkaryotype 46,XX,t(9;22;2;5). Conclusion: This study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding thesetranslocations in leukemias.
