Author/Authors :
Pozio, Alfonso IDROCOMB - ENEA, Italy , Palmieri, Annalisa University of Ferrara - Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, Italy , Girardi, Ambra University of Bologna - Centre of Molecular Genetics, CARISBO Foundation - Histology, Embryology and Applied Biology, Italy , Cura, Francesca University of Bologna - Centre of Molecular Genetics, CARISBO Foundation - Histology, Embryology and Applied Biology, Italy , Carinci, Francesco University of Ferrara - Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, Italy
Abstract :
Background: Titanium is the gold standard among materials used for prosthetic devices because of its good mechanical and chemical properties. When exposed to oxygen, titanium becomes an oxide, anatase that is biocompatible and able to induce osseointegration. Materials and Methods: In this study we compared the expression profiling of stem cells cultivated on two types of surface: Pure titanium disk and nanotube titanium disk in order to detect if nanotube titanium instead (NTD) surface stimulates stem cells towards osteoblast differentiation. Results: Stem cells cultivated on nanotube titanium disks showed the upregulation of bone‑related genes RUNX2, FOSL1 and SPP1. Conclusions: Results demonstrated that nanotube titanium disk surface is more osteo‑induced surface compared to titanium disk, promoting the differentiation of mesenchymal stem cells in osteoblasts.
Keywords :
Gene expression , nanotubes , osteoblasts , stem cells , titanium disks
