Author/Authors :
Scapoli, Luca University of Bologna - Departments of Histology, Embryology and Applied Biology, Italy , Girardi, Ambra University of Bologna - Departments of Histology, Embryology and Applied Biology, Italy , Palmieri, Annalisa University of Ferrara - Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, Italy , Carinci, Francesco University of Ferrara - Department of D M C C C , Department of Medical-Surgical Sciences of Communicationand Behavior, Section of Maxillofacial and Plastic Surgery, Italy , Testori, Tiziano Galeazzi Hospital, Italy , Zuffetti, Francesco Galeazzi Hospital, Italy , Monguzzi, Riccardo , Lauritano, Dorina University Milano Bicocca - Neurosciences and Biomedical Technologies, Italy
Abstract :
Background: Periodontitis is a disease mainly caused by a chronic infection of tissues that support the teeth. Several factors, such as diabetes, smoking and oral care, as well as genetic susceptibility can influence both the risk to develop periodontitis and its progression. The aim of the investigation was to test whether alleles of candidate genes were associated with periodontitis. Materials and Methods: A case control study was performed with a cohort of 184 patients with chronic periodontitis and 231 healthy controls from the Italian population. A total of six single nucleotide polymorphisms from five candidate genes, i.e., IL1A, IL1B, IL6, IL10 and vitamin D receptor, were investigated. Results: Evidence of association were obtained for rs1800795 mapping in IL6 (P value = 0.01) as well as for the rs1800872 mapping in IL10 (P = 0.04). The rarer variant allele lowered the risk to develop periodontitis at IL6 (Odds Ratio [OR] = 0.69 [95% confidence interval {CI} 0.51-0.93]) and increased the risk at IL10 (OR = 1.38 [95% CI 1.01-1.86]). Conclusions: The present investigation indicated that polymorphisms of IL6 and IL10 constitute risk factors for chronic periodontitis, while there was no evidence implicating a specific IL1A or IL1B genotype.
Keywords :
Bone resorption , genes , inflammation , periodontal disease , polymorphism
