HYDROGEN PEROXIDE EFFECTS ON IMMUNE RESPONSES (CELLULAR AND HUMERAL ) IMMUNITY OF ADULT MALE RABBITS

This study was designed to investigate the effects of 0.5% hydrogen peroxide H2O2 and levamizole drug on immune response of adult male rabbits. Twenty four mature male newzeland were randomly divided into two groups and were treated as follow for four weeks: Control group(C) and H2O2 treated group (GI) which were daily intubated with 0.5% H2O2 in drinking water. After cessation of H2O2 intubation (4weeks), animals of GI group where intubated (each 72 hrs) with levamizole (5mg /Kg B.W.) in drinking water for another four weeks . Blood samples were taken at zero, 4 and 8 weeks of the experiment to determine some blood and immune response parameters including: differential leukocytes count, total leukocytes count (TLC), active and T- lymphocytes, neutrophil/lymphocyte (N/L) index, platelets count , phagocytic activity and IgG concentration. The results conducted that H2O2 treated group showed significant decrease (p 0.05) in some blood and immune response parameters manifested by leucopenia, lymphocytopenia, thrombocytopenia and a significant increase (P 0.05) in N/L index with significant suppression in the percentage of active and total lymphocyte, phagocytic activity and serum IgG concentration. On the other hand, levamizole treatment leading to a significant increase (P 0.05) in the immune response parameters and a significant decrease (P0.05) in N/L index.