Author/Authors :
Zhang, Yu Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Zhang, Ziye Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Zhang, Lina Department of Biostatistics - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Zhao, Sheng Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Zhao, Jing Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Ye, Qing Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Gao, Yingli Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Jiang, Chenyi Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Cui, Di Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Xia, Shujie Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Han, Bangmin Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China , Jing, Yifeng Department of Urology - Shanghai General Hospital - Shanghai Jiao Tong University School of Medicine - Shanghai, China
Abstract :
Purpose: To investigate the clinical implications of CD+3CD+69 T-cells and CD+8CD+28 T-cells in the peripheral blood of patients prior to radical prostatectomy.
Materials and Methods: A total of 91 prostate cancer (PCa) patients and 50 benign prostatic hyperplasia (BPH) patients were enrolled from January 2016 to December 2017. The proportions of CD+3CD+69 T-cells and CD+8CD+28 T-cells in the peripheral blood of PCa and BPH patients were detected by flow cytometry, and the association of these T-cell populations with pathological Grade Group and pathological TNM classification was evaluated. Data analysis was performed with SAS version 9.4 software.
Results: The proportions of CD+3CD+69 and CD+8CD+28 T-cells in peripheral blood were higher in PCa
patients than those in BPH patients. Multivariate analysis identified a higher CD+3CD+69 T-cell proportion as a
risk factor for PCa (odds ratio (OR) = 4.783, P = 0.0013), but the diagnostic efficacy of the CD+3CD+69 T-cell
proportion (area under the curve (AUC)=0.6833, P = 0.0003) for PCa was still inferior to that of the tPSA level
(AUC=0.7531, P < 0.0001). The AUCs for CD+3CD+69 T-cell and CD+8CD+28 T-cell proportions for PCa were
0.6959 (P = 0.0372) and 0.6935 (P = 0.0395), respectively, among men with tPSA levels of 10.0-4.0 ng/mL. A
lower CD+3CD+69 T-cell proportion was associated with higher pathological Grade Group (P=0.0074).
Conclusion: The proportions of CD+3CD+69 T-cells and CD+8CD+28 T-cells in peripheral blood are potential
diagnostic indicators for PCa. The preoperative proportion of CD+3CD+69 T-cells in peripheral blood may have prognostic value in terms of the pathological Grade Group in PCa.
Keywords :
CD+3CD+69 T-cell , CD+8CD+28 T-cell , immune function , prostate cancer , radical prostatectomy
