Genetical Effect of Flavonoids Extracted from the Leaves of Camellia sinensis on Mice

This study was in AL-Nahrain Research Center/University of AL-Nahrain in 2009, examine the role of flavonoids extracted from Camellia sinensis leaves in the inhibition effects of genotoxicity of the chemical Methotrexate (MTX)in mice and depended on some genetic analyzes, which includes the Mitotic index, Chromosomal aberration assay and Micronucleus test in the bone marrow of the mice. This study showed that methotrexate (MTX) agent had toxic effect on cytogenetic by decreasing the mitotic index and increasing the chromosomal aberrations and micronucleus in the bone marrow while the flavonoids extract showed anti-mutagenic activity against methotrexate (MTX) by increasing the mitotic index and decreasing the chromosomal aberrations and micronucleus in the bone marrow.