Title of article :
Contribution of IL-10 (SNP -819 C/T and SNP-1082 G/A) polymorphisms variants to the risk of type 1 diabetes in Egyptian population
Author/Authors :
Al-shehmany, Ali Salim Alexandria University - Institute for Governmental Service and Research (IGSR) - Department of Biotechnology, Egypt , El-Kafoury, Ahmad A. Alexandria University - Faculty of Medicine - Department of Pediatric, Egypt , Haroun, Medhat A. Alexandria University - Institute for Governmental Service and Research (IGSR) - Department of Biotechnology, Egypt , Embaby, Amira M. Alexandria University - Institute for Governmental Service and Research (IGSR) - Department of Biotechnology, Egypt
Abstract :
This study investigated whether interleukin- 10 (IL-10) gene promoter region polymorphisms are associated with susceptibility or clinical presentation of type 1 diabetes. The frequency of - 1082G/A and -819C/T, polymorphisms was analyzed in 60 Egyptian patients with type 1 diabetes and in 60 healthy control subjects in a case-controlled study. However, the -819C/T not showed significance between patient and control (P=0.208) and 1082G/A were associated with T1DM disease (P 0.0001). These results suggest that the IL-10 gene promoter polymorphisms are associated with type 1 diabetes in Egyptian population.
Keywords :
IL , 10 interleukin , 10 polymorphisms , type 1 diabetes.
Journal title :
iraqi journal of biotechnology
Journal title :
iraqi journal of biotechnology
