Title of article
Apoptosis and Necrosis Levels in Chemotherapy Treated Chronic Lymphocytic Leukemia Patients
Author/Authors
AL-Faisal, Abdul Hussein Moyet Baghdad University - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies, Iraq , Abdul Hassan, Manal Lafta Baghdad University - Institute of Genetic Engineering and Biotechnology for Postgraduate Studies, Iraq
From page
39
To page
45
Abstract
The results showed that CLL patients chemotherapy treatment increase the expression of Bcl2 gene (via measuring the phosphatidylserine -PS level) which increased apoptosis and necrosis percentage. It is also showed that the Necrotic cells (%) were found to be significantly higher in patients samples (1.07 ± 0.03) than in healthy (0.17 ± 0.02) with no significance in viable cells (%) (82.88% in patients and 86.8% in healthy). The apoptotic cells % were found to be significantly higher in patients (15.04 ± 1.03) than healthy (4.40 ± 0.5). On the other hand, late apoptosis % showed no significant results (0.639 % in patients and 0.803 % in healthy).
Keywords
CLL , Apoptosis , Bcl2 , Mutations , PCR
Journal title
iraqi journal of biotechnology
Journal title
iraqi journal of biotechnology
Record number
2637139
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